Halohydrin Dehalogenase able to Remove Halogen and Open Ring of Epoxides 
Catalog Number IE-1385
Physical Form Liquid
Color Brown to dark brown
Dosage Parameters 0.1-1 kg/T of raw material
Source Microorganism
| Summary | The enzyme reversibly acts on vicinal hydroxyhalides (vicinal halohydrins) to form epoxides and open the epoxides, which can be used for the synthesis of various chiral pharmaceuticals and fine chemicals. |
| Description | Halohydrin Dehalogenase is produced by submerged fermentation followed by separation, ultrafiltration and formulation. The enzyme reversibly acts on vicinal hydroxyhalides (vicinal halohydrins) to form epoxides and open the epoxides. |
| Mechanism | Halohydrin Dehalogenase catalyzes the chemoenzymatic removal of halogens from vicinal halohydrins, generating chiral epoxides through an intramolecular nucleophilic substitution mechanism. It can catalyze the ring-opening reaction of epoxides in the presence of nucleophilic reagents such as CN-, N3-, SCN-, and OCN-, producing chiral β-substituted alcohols, and forming new C-N, C-C, and C-O bonds. Chiral epoxides and β-substituted alcohols are key chiral building blocks for the synthesis of various chiral pharmaceuticals and fine chemicals, with broad application prospects. |
| Advantages | Removal of halogens from vicinal halohydrins; catalyze the ring-opening reaction of epoxides in the presence of nucleophilic reagents; the synthesis of various chiral pharmaceuticals and fine chemicals |
| Application | For the synthesis of various chiral pharmaceuticals and fine chemicals, with broad application prospects |
| Application Area |
Food Biosynthesis |
| Application Recommendation | The recommended dosage is 0.1-1 kg/T of raw material. The dosage has to be optimized based on real situation, the raw material specifications, product expectations and processing parameters. It is better to begin the test with the smallest quantity. |
| Dosage Parameters | 0.1-1 kg/T of raw material |
| Optimum Temp | 30-40°C |
| Effective Temp | 20-50°C |
| Optimal pH | 5.0-7.0 |
| Effective pH | 4.0-8.0 |
| Source | Microorganism |
| Physical Form | Liquid |
| Color | Brown to dark brown |
| Scope of Shipment | Worldwide |
| Package | 25 kg/jerry can (customizable) |
| Storage | Keep sealed in a dry place at below -8°C and avoid direct sunlight. |
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