AMP Nucleotidase for Drug Development and Diagnosis 
Catalog Number IE-1380
Physical Form Liquid
Color Brown to dark brown
Dosage Parameters 0.1-1 kg/T of raw material
Source Microorganism
| Summary | The enzyme hydrolyzes the bond between sugar and phosphate in adenosine monophosphate, producing inorganic phosphate and nucleosides. |
| Description | AMP Nucleotidase is produced by submerged fermentation followed by separation, ultrafiltration and formulation. The enzyme refers to the specific phosphatase that hydrolyzes the bond between sugar and phosphate in adenosine monophosphate, producing inorganic phosphate and nucleosides. |
| Mechanism | AMP Nucleotidase is a compound composed of purine or pyrimidine bases, ribose or deoxyribose, and phosphate. It is also known as a nucleotide. The synthesis of nucleosides occurs when pentose and organic bases combine, while the synthesis of nucleotides occurs when nucleosides combine with phosphate. The four nucleotides form nucleic acids. Nucleotides are mainly involved in the construction of nucleic acids, and many mononucleotides have various important biological functions, such as adenosine triphosphate (ATP) related to energy metabolism and coenzymes. Certain nucleotide analogs can interfere with nucleotide metabolism and function as anticancer drugs. Nucleotides can be classified as ribonucleotides and deoxyribonucleotides based on the different sugars. They can also be classified based on different bases, such as adenosine monophosphate (adenylate, AMP), guanosine monophosphate (guanylate, GMP), cytidine monophosphate (cytidylate, CMP), uridine monophosphate (uridylate, UMP), thymidine monophosphate (thymidylate, TMP), and inosine monophosphate (inosinate, IMP), among others. The phosphate in nucleotides exists in various forms with one, two, or three phosphates. Additionally, nucleotides can undergo dehydration condensation to form cyclic nucleotides. Nucleotides are the basic building units of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) and serve as precursors for nucleic acid synthesis. Nucleotides are distributed in the nucleus and cytoplasm of organs, tissues, and cells in living organisms and participate in fundamental life processes such as inheritance, development, and growth as components of nucleic acids. There are also considerable amounts of nucleotides present in their free forms. Adenosine triphosphate plays a major role in cellular energy metabolism. The release and absorption of energy in organisms are mainly reflected by the production and consumption of adenosine triphosphate. Additionally, adenosine monophosphate, cytidine monophosphate, and guanosine monophosphate serve as energy sources in some biosynthesis pathways. Adenylate is also a component of certain coenzymes such as coenzyme I, II, and coenzyme A. |
| Advantages | Improve the production of recombinant proteins; develop new drugs and diagnostic tools |
| Application | For development of new drugs and as diagnostic tools |
| Application Area |
Food Biosynthesis Diagnosis |
| Application Recommendation | The recommended dosage is 0.1-1 kg/T of raw material. The dosage has to be optimized based on real situation, the raw material specifications, product expectations and processing parameters. It is better to begin the test with the smallest quantity. |
| Dosage Parameters | 0.1-1 kg/T of raw material |
| Optimum Temp | 25-35°C |
| Effective Temp | 20-50°C |
| Optimal pH | 6.0-7.0 |
| Effective pH | 5.0-8.0 |
| Source | Microorganism |
| Physical Form | Liquid |
| Color | Brown to dark brown |
| Scope of Shipment | Worldwide |
| Package | 25 kg/jerry can (customizable) |
| Storage | Keep sealed in a dry place at below -8°C and avoid direct sunlight. |
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